Propolis
has been around for over 40 million years and has been used by
man both internally and externally even before the time of
Christ as a healing agent.
Originated from the Greek word,
"PRO", meaning "in defense of" and "POLIS" meaning
"city", bee propolis extract is now considered an important part
of dietetics and a natural cure by the World Health
Organization.
To make simple, we can think of
propolis as bees own medicine.
It is a mixture of various amounts
of resins collected by the honeybees from plants - particularly
from flowers, leaf buds and the bark of trees.
Carried on their back legs, bees
use propolis as some sort of natural cement to strengthen and
seal cracks in their hives.
The question is, why do the bees
use propolis when there are all sorts of natural glue available
in nature? This is where it gets interesting.
The Need for Protection
Just imagine living in a super crowded apartment, sharing it
with other 50,000 living beings. The apartment is so small, it's
hard for you even to get in or out of your home. It's like
making a crowded Tokyo subway your home.

If you're living in such a tight space, you know that you need a
strong structure to hold the busy units, but more importantly
you also need a way to keep the whole apartment clean and free
of bacteria. Just one "unclean" occupant can bring massive
disease outbreak in the whole kingdom.
This is what it feels like living in a bee hive. These bees must
find a way to avoid bacterial and viral infection from spreading
in their congested home. Without some kind of antibiotics
protection, the whole colony could be dead.
Propolis as God sent Protection
Luckily for these bees, nature provides them with a solution.
What they do is collect the substance that trees use to protect
itself from infection and use it in their homes.
Certain trees like poplar, willow, birch and horse chestnut
produce a special antibiotic sap to protect it from infection.
Bees gather these saps, took it back to their hives and coat
their hives the with it, in much the same way we use to paint
and caulk our home.
It will seal, line and strengthen the hives. The best thing is
that when they brush against these brownish substance, the honey
bees become immunized.
That special substance is what we now call propolis, a term
coined by the Greek to mean "Defender of the City".
What’s in Bee Propolis?
Chemically, propolis is exceedingly complex. Flavonoids are
abundant in propolis. Apart from that you will also find
kaempferol, apigenin, pinocembrin, galangin, luteolin,
pinostrobin and quercitin, all of which are anti-inflammatory,
antiallergenic, antioxidant and/or antimutagenic.
Propolis is also rich in the caffeic acid phenethyl ester. This
is a substance that was shown to inhibited cancer growth and
reduced inflammation studies done to animals.
Bee propolis also contains organic acids and their derivatives
as well as terpenoids. These constituents contribute antibiotic,
anti fungal and antiviral effects.
About Propolis Antibacterial and Antiviral Effects
There is an interesting difference between propolis's
antibacterial property compared to an antibiotics.
Antibiotics works by killing bacteria in our body, That includes
those "friendly" ones needed by the body. Among the friendly
bacteria killed by antibiotics are bacteria responsible in
helping the body produce vitamins like B and K. The more
antibiotics you use, the more friendly bacteria will you kill.
At the end of the day, you might be deficient in those vitamins,
not mentioning other vast side effects you will get from prolong
use of antibiotics.
On the other hand, propolis raise the body's natural resistance
by stimulating one's own immune system. It will also add certain
vitamin like B1, B, C, E and essential minerals including iron,
aluminum, manganese and silicon to the body.
Thus, scientist have tried to combine antibiotics and propolis
to get the best of both worlds. They found that addition of
propolis to antibiotics increases the effect of the drug from 10
to 100 folds.
Health benefits of Propolis
Although the fact that propolis has been used for thousands of
years may be enough to convince people on propolis benefits, we
dig scientific journals to satisfy some skeptics.
Let's see how medical science conforms ancient wisdom.
Improving Immune System
Professor S. Scheller, the head of a team of four doctors at the
Institute for Microbiology at the Medical Academy in Poland
found that propolis is able to stimulate the immune system.
It stimulates the formation of antibodies to build body
resistance to many diseases. It also help the body in releasing
substance against cellular deterioration.
He also concluded that other propolis health benefits may
include improved physical , intellectual and sexual performance
and makes injured tissue heal faster.
The study also found that propolis is non toxic.
Treat Burns
Another benefits of propolis is in treating second degree burns.
Research showed that propolis cream gave about the same result
as currently prescribed cream.
However, propolis cream reduce patient's inflammation and lead
to a faster healing.
Various studies have confirmed that propolis stimulates enzyme
systems, cell metabolism, circulation, collagen formation and
improved healing of burn wounds.
It is believe to be a result of a substance called arginine.
Increase Fertility
One isolated study had tested
the benefit of propolis on women with infertility and
endometriosis. The study indicated that consumption
of 500mg of propolis twice daily resulted in pregnancy rate of
60% as opposed to 20% for women not given propolis.
It is still unclear how propolis would give this effect.
Potential Cancer Drug
A report published in the Cancer Research (Sep 15,93;53 1482-88)
stated that caffeic acids in propolis might help prevent colon
cancer. The article described how these caffeic acids were able
to prevent the formation of pre cancerous tissues in rats after
the animal were exposed to cancer causing chemicals.
Another study done in 1990 showed propolis chemicals to act
against ovary cancer in hamster and sarcoma-type tumors in mice.
Bowel Problems
Propolis can also benefit patients suffering from inflammatory
bowel problems like Chron's disease and ulceration colitis.
In June 2001, Dr. Ralph Golan reported how ulceration colitis
responded well to propolis therapy. This was reported in his
article published in Townsend Letters For Doctors.
Dental care
Another benefit of bee propolis is in dental care. Propolis
mouthwash used after an oral surgery appears to shorten the
healing time. A study done in 1991 showed that rats given
propolis in their drinking water got less caries compared to
other rats.
Another study done in 1986 proposed propolis as a valuable
subsidiary treatment for gum infection and plague.
It is also used in dental surgery as natural and safe
disinfectant.
Protecting Liver
Two studies done in 1986 and 1987 showed that another benefits
of propolis is in protecting liver. It was shown to be effective
in protecting liver against alcohol and tetrachloride.
Improve Antibiotic Effectiveness
Australian scientists, E.L Ghisalberti of the Department of
Organic Chemistry at the University of Western Australia showed
that propolis increases the effectiveness of penicillin or other
antibiotics from 10 to 100 folds.
The combination of these drugs and propolis can cause the drug
dosage to be trimmed down. In conclusion, this discovery will
will cause less side effects of antibiotics and lower the over
dependency on antibiotics by doctors.
Veterinary Applications
Propolis offers some benefits to breeders by improving weight
gain and reduce diarrhea in their animals.
A study done in 1987 showed that 5 ml of propolis solution given
to milk-fed calves archived the above results.
Studies done to rabbits have also showed that propolis treated
coccidiosis and eimeria. It also is beneficial in treating
mastitis.
Other medical benefits of propolis
Studies done in rats and mice showed that concentrated propolis
given to the animals reduces blood pressure, produces sedative
effect, protects the liver and stomach against tetrachloride and
ulcers. All these are achieved without any side effects.
References: ASRM 2003 Annual Meeting: Abstract O-84, Clinica
chimica acta; international journal of clinical chemistry
Issue: 2003; 338(1-2):11-6 ISSN :0009-8981;
Laboratory of Microbiology and Biomaterials, Renata Cairo do
Amaral etc. School of Dentistry, Universidade Federal de Minas
Gerais, Belo Horizonte, Brazil.